Project News

The CCGP celebrates milestone completions

The Canadian Cattle Genome Project (CCGP) celebrated the completion of 2 huge milestones on April 1, 2014. The project completed sequencing of 315 animals and genotyping (770K and 50K) of over 10,000 animals. Most of the animals sequenced and genotyped are key historic bulls (including some animals born as early as 1900) that have had a major influence on our current Canadian herds.

Decisions on which animals to sequence and genotype were based on an analysis of the pedigree and breed structure for each breed. The top 30 key ancestors for each breed were chosen for sequencing with the goal of representing 50-60% of the effective genome. Further animals were chosen for genotyping based on strategies developed to cover over 90% of the genetic base and to avoid duplication of close relatives.

The CCGP is in the final year of its 3-year project. All of this sequence and genotype data will now be used in the development of improved imputation tools to deliver imputed genotypes. These imputed genotypes will establish the reference training data sets for future delivery of genomic selection for purebred and crossbred animals. As well, appropriate methods for application of genome-wide selection using the imputed high density and sequence genotypes will be implemented.

From the large number of sequenced animals, we have identified millions of sites of variants in the bovine genome, most of which (more than 80%) are previously unknown. With the data from the 1000 Bulls Genome Project, we will be able to get more than 30 million sites of variation, all of which will be used for imputation and phenotype association studies in the project.

Meet The Canadian Cattle Genome Project Stakeholders

Contacts

Paul Stothard
Project Leader
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Steve Miller
Project Leader
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Steve Moore
Project Leader
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Mary De Pauw
Project Manager
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